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About Cube Chem

Bridging global pharma: a partner in the API supply chain

A pharmaceutical trading company and API importer in Heythuysen, the Netherlands — connecting qualified manufacturers with the European healthcare industry.

Introduction

A critical link between manufacturers and European healthcare

Cube Chem B.V. is a specialised pharmaceutical trading company and importer based in the Netherlands. Strategically located in the logistics heart of Europe, we serve as a critical link between high-quality global manufacturers and the European healthcare industry.

We serve pharmaceutical compounders, hospitals, manufacturers and licensed distributors — business-to-business only, and only after verification.

Empty, clean hall with a blue resin floor and windowed walls

Our mission

Secure, compliant sourcing of APIs

We are dedicated to the secure and compliant sourcing of active pharmaceutical ingredients (APIs), with a specialised focus on anaesthetics and controlled substances. Our goal is a reliable, uninterrupted supply chain for pharmaceutical compounders, hospitals and manufacturers, in line with EU quality standards.

  • GMP certificate (QCAS), 2025
  • API registration: pending (CIBG)
  • Opium Act exemption: application in process

Controlled substances are offered and supplied only once the required authorisations (Opium Act exemption, import/export authorisations from Farmatec/IGJ) have been granted, and only to licensed entities.

See where our authorisations stand

Quality & compliance framework

Regulatory compliance at the core of our operations

From our facility in Heythuysen, we put regulatory compliance first. We do not compromise on safety.

  • GMP · GDP

    GMP/GDP standards

    We work to Good Manufacturing and Good Distribution Practice, so that product integrity is maintained from the factory to final delivery.

  • IGJ · Farmatec

    Regulatory alignment

    We coordinate with the Dutch Healthcare Inspectorate (IGJ) and Farmatec on Opium Act exemptions and import authorisations.

  • EU-GMP · CEP

    Vetted suppliers

    We only partner with manufacturers holding valid Certificates of Suitability (CEPs) and EU-GMP certification.

  • Ph. Eur. · USP

    Pharmacopoeial quality

    APIs are sourced to European Pharmacopoeia (Ph. Eur.) or USP specifications, with a Certificate of Analysis (CoA) for every batch.

Our strategic advantage

In the logistics heart of Europe

Located in the Netherlands, Cube Chem B.V. benefits from one of the world’s most advanced pharmaceutical logistics infrastructures. Our central position allows efficient customs clearance and fast distribution throughout the Schengen area — a gateway for non-EU manufacturers entering the European market.

Why Cube Chem?

Transparency and security in a complex market

In a complex global market, Cube Chem B.V. stands for transparency and security. We take on the regulatory complexity and import restrictions, so our partners can focus on what matters most: patient care and production excellence.

  • Focused on high-complexity APIs

    Unlike generalist distributors, we focus on high-complexity APIs, including anaesthetics and substances under the Opium Act, and on the regulatory knowledge they require.

  • A bridge to the European market

    We connect FDA- and EU-GMP-approved manufacturers with the European market, with CEP/DMF documentation available.

  • Regulation handled for you

    We navigate EU import regulations for our partners — from Opium Act procedures to customs clearance and GDP-compliant transport.

  • Tailored solutions

    We work closely with clients on tailored solutions that improve efficiency and cost-effectiveness.

Commercial partnership models

How we work together commercially

  • Transparent contracting

    We trade on transparent international terms (Incoterms 2020) and work with clear written supply agreements, for mutual security and compliance in long-term partnerships.

  • Volume-based procurement

    We consolidate demand to optimise logistics and pricing, with tiered volume structures for manufacturing partners to keep API costs competitive through economies of scale.

  • Financial stability

    As a Dutch company, we work with established trade-finance instruments to support smooth transactions for both our suppliers and our clients.

Regulatory status

Where our authorisations stand

We publish our status openly, so partners can see what is in place and what is still in progress.

  1. Quality system

    GMP certificate (QCAS), 2025

    Certified

  2. API registration

    Pending (CIBG)

    Pending

  3. Opium Act exemption

    Application in process

    In process

Controlled substances are offered and supplied only once the required authorisations (Opium Act exemption, import/export authorisations from Farmatec/IGJ) have been granted, and only to licensed entities.

Status as published by Cube Chem B.V.

  • Filled core: in place
  • Open core: pending
  • Hatched core: in process
Compliance noticeB2B · KYC

Restricted access

B2B only

Cube Chem B.V. works exclusively with licensed pharmaceutical entities. We do not supply individuals, retailers or non-licensed entities.

Verification first

Every inquiry goes through our Know Your Customer (KYC) process. We verify valid pharmaceutical licences (GDP/GMP) and, where controlled substances are concerned, Opium Act exemptions before any commercial engagement.

Product information

Product details, specifications and pricing are released only after successful verification.

Work with Cube Chem

Partnerships start with verification. Tell us who you are and what you need — product details follow after KYC.

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